Boston, MA

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as a Research Senior Scientist where you will will work with others on the team to design DNA constructs to be used for various therapeutic modalities, such as protein expression in HEK and CHO cells, CARTs and bispecifics, and be abreast with current scientific research and industry design. You will also contribute to the team's efforts to increase expression levels to allow smaller volume and higher throughput methods. As part of the Therapeutic Generation and Screening (TGS) team, you will report to the Associate Director and work with the Global Biologics organization.How you will contribute:Have a solid understanding of biologics and novel antibody designs.Contribute to multiple projects, being a senior scientific consultant and guide the teams on which isoforms are relevant for target design.Have extensive experience in molecular biology and reformatting protein/antibody workflows for expression and experience designing engineering solutions (multispecifics and innovative non-antibody fusions) for projects is also required.Experienced in intellectual property aspects as related to design and is experienced with bioinformatics approaches and algorithms that aid design.Have expertise in various molecular biology databases at NCBI, Uniprot, etc, and various molecular biology software tools, such as Geneious Prime and Biologics, Genedata Biologics, and Snapgene.Work collaboratively and effectively in a multi-disciplinary team environment as a team player, yet independently manage projects and lab work.Multitask and work independently to meet aggressive timelines.Design and direct research strategy and activities to meet program objectives; provide leadership, timelines and contingency plans.Collaborate on Global Biologics project teams representing Therapeutic Generation and Screening.Minimum Requirements/Qualifications:PhD degree in a scientific discipline, Molecular Biology, Biochemistry, Biology, Bioinformatics etc., with 3+ years experience , orMS with 9+ years experience, orBS with 11+ years experienceDemonstrated skills in molecular biology, plasmid design, and protein expression in mammalian cells.Extensive hands-on molecular biology skills in plasmid creation and biologics design.Knowledge and understanding of nucleotide sequences and domains such as those found in CARs, bispecifics, and other modalities. Knowledge of promoters, IRESs, regulatory elements and other protein domains in retroviral or lentiviral constructs that can improve construct expression. Familiarity with common lentiviral vectors and other backbone vectors used for expression.Understanding of chimeric antigen receptor structure and function and their expression in immune cells.Experience working with CROs for gene synthesis.Experience with Genedata and state of the art DNA inventory systems is required.Familiarity with NGS protocols and data analysis is a plus.What Takeda can offer you:Comprehensive Healthcare: Medical, Dental, and VisionFinancial Planning & Stability: 401(k) with company match and Annual Retirement Contribution PlanHealth & Wellness programs including onsite flu shots and health screeningsGenerous time off for vacation and the option to purchase additional vacation daysCommunity Outreach Programs and company match of charitable contributionsFamily Planning SupportFlexible Work PathsTuition reimbursementMore about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.In accordance with the CO Equal Pay Act, Colorado Applicants Are Not Permitted to Apply.#LI-SGMEEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsCambridge, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time